Annual Meeting – Workshops
Two pre-meeting workshops will be held at SIMB Annual Meeting 2012. Both all-day workshops will be held Sunday, August 12 at the Washington Hilton Hotel.
Workshop 1
Fermentation Basics
Fees:
$375 SIM Member
$525 Non-member
$188 Students
Organizer: Mark Berge, Medimmune
This workshop’s focus is to provide individuals with an introduction to fermentation concepts in industrial settings. The workshop will be lecture-based with visual aids to help the attendees understand the fermentation principles discussed. The workshop will be broken into sections based upon the topics that are being presented. After each section has been completed, the attendees will be given real life fermentation case studies that they will work through to reinforce the just discussed topics. The first section of the workshop will include topics on fermenter design including aspect ratios, agitator design, sparger design and sterilization of equipment and media. The second section will deal with actual operational issues of fermentation processes. Included will be discussions about media considerations, foam control strategies, shear, mixing, aeration, feeds and different types of fermentations and the controls involved. The workshop will finish with a section that covers issues involved in scale-up to production size fermentors.
Mark Berge
2010-Current: Sr. Scientist at MedImmune, Inc. in the Process Cell Culture & Fermentation group leading a team responsible for fermentation and cell culture process development activities. 2006-2010: Sr. Scientist at Amgen Inc. in Cell Science & Technology group developing processes for therapeutic protein production using fermentation. 1999-2005: Sr. Scientist at Pfizer Inc. in Global Biologics division developing processes for therapeutic protein production using cell culture. 1995-1999: Process Engineer at FermPro Manufacturing in deep tank toll manufacturing for varied customers of food grade materials. Mark holds a B.S. and M.S. in Chemical Engineering from the University of New Hampshire.
Workshop 2
Advanced, parallel upstream screening and process development: Maximizing culture consistency to get the most out of lab-scale Design of Experiment (DoE) efforts.
Supported by: Applikon Biotechnology Inc.
Fees:
$375 SIM Member
$525 Non-member
$188 Students
Organizer: David Laidlaw, Kuhner Shaker Inc.
Driven by Quality by Design (QbD) initiatives, Design of Experiment (DoE) approaches to fermentation and process development ask more of our upstream bench-scale experiments than ever before. This educational workshop will teach theoretical and practical implementation of tools and technologies intended for upstream screening and process development experiments. The workshop will cover many commonly used laboratory tools and will emphasize their practical use in the laboratory with hands-on training. This workshop will not lecture on Design of Experiments but will instead emphasize the use of proper laboratory techniques and tools so that process-defining experiments are conducted under characterized and reproducible conditions.
The tools featured in this workshop would generally be implemented upstream of stirred tank bioreactors. Starting with advanced well-plates (sensors and fed-batch) the lectures will progress through advanced shake flasks (sensors, fed-batch, off-gas), controlled well-plate systems and ultimately conclude at miniature stirred tank bioreactors. The lectures will review and explain published engineering and characterization data for these platforms and show how to use this information to improve daily experiment routines and generate higher quality results. Lectures will be presented in a training format and will prepare the participant for afternoon of rotating workstations. It is during the afternoon workstations that participants will put newly-learned skills to use. The series of (5 or 6) workstations will allow attendees to obtain hands-on experience with the equipment and ask applications-specific questions of the mornings presenters.
David Laidlaw
Biologist and CEO North American Operations, Kuhner Shaker Inc.
Dave Laidlaw is an active community member in the field of small-scale fermentation and cell culture process control and instrumentation. Having completed graduate studies in the Biotechnology Laboratory at the University of British Columbia, Mr. Laidlaw has worked as a process development scientist and an equipment development specialist. It is with this background that David brings an end-user perspective to upstream screening and technology development. Prior to joining Kuhner Shaker Inc., David held positions of Small-Scale Technologies Manager at Applikon Biotechnology Inc., Applications Development at MicroReactor Technologies Inc. and in Fermentation Process Development at Genentech Inc.
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